How Excedrin Works

The ingredients in Excedrin work together to ensure effective pain relief for different kinds of pain.

How caffeine and aspirin work together

Caffeine is referred to as an ‘analgesic adjuvant’. This means that it helps to boost the effects of certain pain relievers. In the case of Excedrin, caffeine boosts the pain-relieving effects of aspirin and acetaminophen – making these medicines up to 40% more effective.

That’s why you’ll find caffeine in almost all Excedrin products. Only Excedrin PM Headache does not contain caffeine, as caffeine consumed too close to bedtime can keep you from getting a good night’s sleep.
How Excedrin PM helps with sleep

Excedrin PM contains diphenhydramine citrate (38mg), which is used as a nighttime sleep aid. It’s recommended that you take Excedrin PM up to 2 hours before going to sleep, to help relieve head pain and help you fall asleep.

How can Excedrin Help?

Different head health needs may need different solutions. Answer a few simple questions, and the product selector will tell you which Excedrin product could be right for you.

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How Excedrin Works

The ingredients in Excedrin work together to ensure effective pain relief for different kinds of pain.

How caffeine and aspirin work together

How Excedrin PM helps with sleep

How can Excedrin Help?

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