Skip to main content
Woman thinking

Does Caffeine Help Migraines and Headaches? Excedrin and Caffeine

Find out how caffeine can help treat your headaches.

If you suffer from frequent headaches, then you understand how important it is to get quick relief. What you may not know is that some medications contain a surprising ingredient that helps alleviate headache pain. The ingredient for managing headaches that makes a big difference: caffeine.1

Where does Caffeine Come From?

Caffeine is found naturally in the fruit, beans and beans of the coffee plant, tea leaves, cacao plants and guarana plants, in different amounts:1

  • Cup of black coffee: 95mg
  • Shot of espresso: 65mg
  • Cup of black tea: 47mg
  • Cup of green tea: 28mg
  • Ounce of dark chocolate (cacao): 24mg
  • Guarana seeds: about four times the amount found in coffee beans
  • Excedrin Extra Strength: 65mg

In the United States, adults consume about 135-200mg of caffeine on average each day, which works out to about a cup and a half of coffee.1,2 Studies suggest that up to 90% of Americans consume at least some caffeine on a daily basis, making this widely available stimulant the world’s most popular drug.2

How Does Caffeine Help Migraines?

The human body creates a substance called adenosine, which is responsible for deep sleep, temporary widening of blood vessels, control of some movement, brain electrical activity, collagen production, and is present in large amounts during a migraine attack.1,2

During a migraine, adenosine sticks to specific receptor molecules on brain cells.2 Caffeine helps migraines by blocking these receptors, which means the adenosine doesn’t have a place to land and cannot exacerbate a headache.2 Another way that caffeine can help during a migraine attack is by reducing inflammation and narrowing blood vessels which may relieve pain.1

Additionally, caffeine can make analgesics work more efficiently, and increase your body’s absorption of pain-relieving medications like Excedrin.3 It functions as an adjuvant, which is a substance that enhances the body’s response to a medication and studies have shown that combining caffeine with other pain medications improves their overall efficacy.3

Simply put, caffeine can help with migraines and headaches by narrowing blood vessels, inhibiting chemicals that can cause migraines. While it’s useful on its own, caffeine is best at helping migraines and headaches by making analgesics like the active ingredients in some Excedrin products more efficient and effective.

Couple smiles while cooking in a kitchen

Save on Excedrin

Get printable coupons and special offers to save on Excedrin.

Get coupons

Can Caffeine Help the Body in Other Ways?

Your body absorbs caffeine within about 45 minutes after you’ve consumed it and peaks in your blood about 15 minutes-2 hours after that.1 It’s absorbed quickly in the stomach and is broken down primarily in the liver.1 This naturally occurring chemical compound is associated with several health conditions in addition to alertness and energy levels, though everyone’s tolerance and reaction may vary by age and genetics:1

  • Diabetes. Caffeine stimulates the release of the hormone epinephrine which causes the body to temporarily raise blood glucose levels.
  • Asthma. Caffeine can help relax the muscles of the lungs and open bronchial tubes, helping the breathing of asthma patients.
  • Neurological disease. Studies indicate that people with higher caffeine intakes have a lower risk for developing Parkinson’s disease.

Pain Relievers that Contain Caffeine for Managing Migraines and Headaches

Three Excedrin products—Excedrin® Extra StrengthExcedrin® Migraine and Excedrin® Tension Headache —contain caffeine. These medications provide quick relief due to a combination of pain relievers and caffeine. Excedrin® Extra Strength may even provide relief in 15 minutes for some people.

Remember to discuss all medications you take for headache or migraine with your doctor, even when taking an over-the-counter product. Products should only be used as directed.

More from Excedrin